Short term treatment of dermatophyte onychomycosis with terbinafine.

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Short term treatment of dermatophyte onychomycosis with terbinafine.

OBJECTIVE To evaluate the effect of short term treatment with terbinafine on dermatophytosis. DESIGN Multicentre, randomised, double blind placebo controlled trial of 250 mg/day terbinafine for 12 weeks in dermatophyte onychomycosis. SETTING Eight dermatology centres in the United Kingdom. PATIENTS 112 patients (mean age 44, range 19-78), 99 with mycologically proved toenail infections an...

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Treatment of Dermatophytic Onychomycosis with Intermittent and Continuous Terbinafine Regimens

The treatment of onychomycosis is a difficult and long-standing course because of the relatively low success and high recurrence rates and the necessity of laboratory monitoring for the traditional oral antifungal agents. The introduction of newer systemic antifungal drugs such as triazoles (itraconazole and fluconazole) and allylamines (terbinafine) offer an increased cure rate, a broader spec...

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Randomized double-blind comparison of short-term itraconazole and terbinafine therapy for toenail onychomycosis.

Previous studies evaluating short-term itraconazole and terbinafine therapy for onychomycosis have varied in protocol and size; this double-blind study enabled a large-scale, standardized, direct comparison. Patients with toenail onychomycosis were randomized to itraconazole 200 mg daily (n = 146) or terbinafine 250 mg daily (n = 146) for 12 weeks, with a 36-week follow-up. Mycological cure rat...

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Pseudo-Clubbing Complicated by Dermatophyte Onychomycosis

Vol. 26 No. 2, 2014 271 Received January 14, 2013, Revised May 6, 2013, Accepted for publication May 8, 2013 Corresponding author: Hong Sang, Department of Dermatology, Jinling Hospital, Nanjing University School of Medicine, No.305, Zhongshan East Road, Nanjing, Jiangsu Provence, 210002, China. Tel: 86-25-80860092, 86-25-84815775, E-mail: [email protected] This is an Open Access article dist...

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Non-dermatophyte moulds as pathogens of onychomycosis.

OBJECTIVE To determine the role and pattern of non-dermatophyte moulds as causative agents of onychomycosis. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY Department of Microbiology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from November 2009 to July 2010. METHODOLOGY Nail clippings and nail scrapings were obtained from abnormal looking nails with treatment and dete...

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ژورنال

عنوان ژورنال: BMJ

سال: 1992

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.304.6835.1151